CGBVS予測モデル(Protease)

予測モデルを選択:

相互作用(リガンド)データ数 ◎:500~、○:100~499、△:1~99、x:0

UniProt ID Accession Number Protein Name Model
ChEMBL22 ChEMBL25
ACE_HUMAN P12821 Angiotensin-converting enzyme
ACE2_HUMAN Q9BYF1 Angiotensin-converting enzyme 2
ACPH_HUMAN P13798 Acylamino-acid-releasing enzyme
ACRO_HUMAN P10323 Acrosin
ADA10_HUMAN O14672 Disintegrin and metalloproteinase domain-containing protein 10
ADA12_HUMAN O43184 Disintegrin and metalloproteinase domain-containing protein 12
ADA17_HUMAN P78536 Disintegrin and metalloproteinase domain-containing protein 17
ADA33_HUMAN Q9BZ11 Disintegrin and metalloproteinase domain-containing protein 33
ADAM8_HUMAN P78325 Disintegrin and metalloproteinase domain-containing protein 8
ADAM9_HUMAN Q13443 Disintegrin and metalloproteinase domain-containing protein 9
AMPB_HUMAN Q9H4A4 Aminopeptidase B
AMPE_HUMAN Q07075 Glutamyl aminopeptidase
AMPL_HUMAN P28838 Cytosol aminopeptidase
AMPN_HUMAN P15144 Aminopeptidase N
ATG4B_HUMAN Q9Y4P1 Cysteine protease ATG4B
ATS1_HUMAN Q9UHI8 A disintegrin and metalloproteinase with thrombospondin motifs 1
ATS13_HUMAN Q76LX8 A disintegrin and metalloproteinase with thrombospondin motifs 13
ATS4_HUMAN O75173 A disintegrin and metalloproteinase with thrombospondin motifs 4
ATS5_HUMAN Q9UNA0 A disintegrin and metalloproteinase with thrombospondin motifs 5
BACE1_HUMAN P56817 Beta-secretase 1
BACE2_HUMAN Q9Y5Z0 Beta-secretase 2
BAP1_HUMAN Q92560 Ubiquitin carboxyl-terminal hydrolase BAP1
BMP1_HUMAN P13497 Bone morphogenetic protein 1
C1R_HUMAN P00736 Complement C1r subcomponent
C1S_HUMAN P09871 Complement C1s subcomponent
CAN1_HUMAN P07384 Calpain-1 catalytic subunit
CAN2_HUMAN P17655 Calpain-2 catalytic subunit
CASP1_HUMAN P29466 Caspase-1
CASP2_HUMAN P42575 Caspase-2
CASP3_HUMAN P42574 Caspase-3
CASP4_HUMAN P49662 Caspase-4
CASP5_HUMAN P51878 Caspase-5
CASP6_HUMAN P55212 Caspase-6
CASP7_HUMAN P55210 Caspase-7
CASP8_HUMAN Q14790 Caspase-8
CASP9_HUMAN P55211 Caspase-9
CASPA_HUMAN Q92851 Caspase-10
CASPE_HUMAN P31944 Caspase-14
CATB_HUMAN P07858 Cathepsin B
CATC_HUMAN P53634 Dipeptidyl peptidase 1
CATD_HUMAN P07339 Cathepsin D
CATE_HUMAN P14091 Cathepsin E
CATF_HUMAN Q9UBX1 Cathepsin F
CATG_HUMAN P08311 Cathepsin G
CATH_HUMAN P09668 Pro-cathepsin H
CATK_HUMAN P43235 Cathepsin K
CATL1_HUMAN P07711 Cathepsin L1
CATL2_HUMAN O60911 Cathepsin L2
CATS_HUMAN P25774 Cathepsin S
CATZ_HUMAN Q9UBR2 Cathepsin Z
CBPA1_HUMAN P15085 Carboxypeptidase A1
CBPA3_HUMAN P15088 Mast cell carboxypeptidase A
CBPB1_HUMAN P15086 Carboxypeptidase B
CBPB2_HUMAN Q96IY4 Carboxypeptidase B2
CBPC2_HUMAN Q5U5Z8 Cytosolic carboxypeptidase 2 ×
CBPM_HUMAN P14384 Carboxypeptidase M
CBPN_HUMAN P15169 Carboxypeptidase N catalytic chain
CELA1_HUMAN Q9UNI1 Chymotrypsin-like elastase family member 1
CFAB_HUMAN P00751 Complement factor B
CFAD_HUMAN P00746 Complement factor D
CMA1_HUMAN P23946 Chymase
CPNS1_HUMAN P04632 Calpain small subunit 1 ×
CSN5_HUMAN Q92905 COP9 signalosome complex subunit 5 ×
CTRB1_HUMAN P17538 Chymotrypsinogen B
CTRC_HUMAN Q99895 Chymotrypsin-C
CTRL_HUMAN P40313 Chymotrypsin-like protease CTRL-1
DNPEP_HUMAN Q9ULA0 Aspartyl aminopeptidase
DPEP1_HUMAN P16444 Dipeptidase 1
DPP2_HUMAN Q9UHL4 Dipeptidyl peptidase 2
DPP4_HUMAN P27487 Dipeptidyl peptidase 4
DPP8_HUMAN Q6V1X1 Dipeptidyl peptidase 8
DPP9_HUMAN Q86TI2 Dipeptidyl peptidase 9
ECE1_HUMAN P42892 Endothelin-converting enzyme 1
ECE2_HUMAN P0DPD6 Endothelin-converting enzyme 2
ELNE_HUMAN P08246 Neutrophil elastase
ENTK_HUMAN P98073 Enteropeptidase
ERAP1_HUMAN Q9NZ08 Endoplasmic reticulum aminopeptidase 1
ERAP2_HUMAN Q6P179 Endoplasmic reticulum aminopeptidase 2
FA10_HUMAN P00742 Coagulation factor X
FA11_HUMAN P03951 Coagulation factor XI
FA12_HUMAN P00748 Coagulation factor XII
FA7_HUMAN P08709 Coagulation factor VII
FA9_HUMAN P00740 Coagulation factor IX
FACE2_HUMAN Q9Y256 CAAX prenyl protease 2
FOLH1_HUMAN Q04609 Glutamate carboxypeptidase 2
FURIN_HUMAN P09958 Furin
GGH_HUMAN Q92820 Gamma-glutamyl hydrolase
GGT1_HUMAN P19440 Glutathione hydrolase 1 proenzyme
GRAB_HUMAN P10144 Granzyme B
HEPS_HUMAN P05981 Serine protease hepsin
HGFA_HUMAN Q04756 Hepatocyte growth factor activator
HYEP_HUMAN P07099 Epoxide hydrolase 1 ×
IDE_HUMAN P14735 Insulin-degrading enzyme
KLK1_HUMAN P06870 Kallikrein-1
KLK12_HUMAN Q9UKR0 Kallikrein-12
KLK13_HUMAN Q9UKR3 Kallikrein-13
KLK14_HUMAN Q9P0G3 Kallikrein-14
KLK2_HUMAN P20151 Kallikrein-2
KLK3_HUMAN P07288 Prostate-specific antigen
KLK4_HUMAN Q9Y5K2 Kallikrein-4
KLK5_HUMAN Q9Y337 Kallikrein-5
KLK6_HUMAN Q92876 Kallikrein-6
KLK7_HUMAN P49862 Kallikrein-7
KLK8_HUMAN O60259 Kallikrein-8
KLKB1_HUMAN P03952 Plasma kallikrein
LCAP_HUMAN Q9UIQ6 Leucyl-cystinyl aminopeptidase
LGMN_HUMAN Q99538 Legumain
LKHA4_HUMAN P09960 Leukotriene A-4 hydrolase ×
MALT1_HUMAN Q9UDY8 Mucosa-associated lymphoid tissue lymphoma translocation protein 1
MAP11_HUMAN P53582 Methionine aminopeptidase 1
MAP2_HUMAN P50579 Methionine aminopeptidase 2
MBTP1_HUMAN Q14703 Membrane-bound transcription factor site-1 protease
MEP1A_HUMAN Q16819 Meprin A subunit alpha ×
MEP1B_HUMAN Q16820 Meprin A subunit beta ×
MMEL1_HUMAN Q495T6 Membrane metallo-endopeptidase-like 1
MMP1_HUMAN P03956 Interstitial collagenase
MMP10_HUMAN P09238 Stromelysin-2
MMP11_HUMAN P24347 Stromelysin-3
MMP12_HUMAN P39900 Macrophage metalloelastase
MMP13_HUMAN P45452 Collagenase 3
MMP14_HUMAN P50281 Matrix metalloproteinase-14
MMP15_HUMAN P51511 Matrix metalloproteinase-15
MMP16_HUMAN P51512 Matrix metalloproteinase-16
MMP17_HUMAN Q9ULZ9 Matrix metalloproteinase-17
MMP2_HUMAN P08253 72 kDa type IV collagenase
MMP20_HUMAN O60882 Matrix metalloproteinase-20 ×
MMP24_HUMAN Q9Y5R2 Matrix metalloproteinase-24 ×
MMP25_HUMAN Q9NPA2 Matrix metalloproteinase-25
MMP26_HUMAN Q9NRE1 Matrix metalloproteinase-26
MMP3_HUMAN P08254 Stromelysin-1
MMP7_HUMAN P09237 Matrilysin
MMP8_HUMAN P22894 Neutrophil collagenase
MMP9_HUMAN P14780 Matrix metalloproteinase-9
NALD2_HUMAN Q9Y3Q0 N-acetylated-alpha-linked acidic dipeptidase 2
NEC1_HUMAN P29120 Neuroendocrine convertase 1
NEC2_HUMAN P16519 Neuroendocrine convertase 2
NEP_HUMAN P08473 Neprilysin
NICA_HUMAN Q92542 Nicastrin ×
PCP_HUMAN P42785 Lysosomal Pro-X carboxypeptidase
PCSK5_HUMAN Q92824 Proprotein convertase subtilisin/kexin type 5
PCSK6_HUMAN P29122 Proprotein convertase subtilisin/kexin type 6
PCSK7_HUMAN Q16549 Proprotein convertase subtilisin/kexin type 7
PCSK9_HUMAN Q8NBP7 Proprotein convertase subtilisin/kexin type 9 ×
PEPA5_HUMAN P0DJD9 Pepsin A-5 ×
PEPC_HUMAN P20142 Gastricsin
PEPD_HUMAN P12955 Xaa-Pro dipeptidase
PLMN_HUMAN P00747 Plasminogen
PPCE_HUMAN P48147 Prolyl endopeptidase
PPGB_HUMAN P10619 Lysosomal protective protein
PREP_HUMAN Q5JRX3 Presequence protease, mitochondrial
PROC_HUMAN P04070 Vitamin K-dependent protein C
PRSS8_HUMAN Q16651 Prostasin
PRTN3_HUMAN P24158 Myeloblastin
PSA_HUMAN P55786 Puromycin-sensitive aminopeptidase
PSA1_HUMAN P25786 Proteasome subunit alpha type-1
PSA2_HUMAN P25787 Proteasome subunit alpha type-2
PSA3_HUMAN P25788 Proteasome subunit alpha type-3
PSA4_HUMAN P25789 Proteasome subunit alpha type-4
PSA5_HUMAN P28066 Proteasome subunit alpha type-5
PSA6_HUMAN P60900 Proteasome subunit alpha type-6
PSA7_HUMAN O14818 Proteasome subunit alpha type-7
PSA7L_HUMAN Q8TAA3 Proteasome subunit alpha type-7-like ×
PSB1_HUMAN P20618 Proteasome subunit beta type-1
PSB10_HUMAN P40306 Proteasome subunit beta type-10
PSB11_HUMAN A5LHX3 Proteasome subunit beta type-11
PSB2_HUMAN P49721 Proteasome subunit beta type-2
PSB3_HUMAN P49720 Proteasome subunit beta type-3
PSB4_HUMAN P28070 Proteasome subunit beta type-4
PSB5_HUMAN P28074 Proteasome subunit beta type-5
PSB6_HUMAN P28072 Proteasome subunit beta type-6
PSB7_HUMAN Q99436 Proteasome subunit beta type-7
PSB8_HUMAN P28062 Proteasome subunit beta type-8
PSB9_HUMAN P28065 Proteasome subunit beta type-9
PSDE_HUMAN O00487 26S proteasome non-ATPase regulatory subunit 14
PSMA8_HUMAN Q8TAA3 Proteasome subunit alpha-type 8 ×
PSN1_HUMAN P49768 Presenilin-1
PSN2_HUMAN P49810 Presenilin-2
RENI_HUMAN P00797 Renin
SENP1_HUMAN Q9P0U3 Sentrin-specific protease 1
SENP2_HUMAN Q9HC62 Sentrin-specific protease 2 ×
SENP6_HUMAN Q9GZR1 Sentrin-specific protease 6
SENP7_HUMAN Q9BQF6 Sentrin-specific protease 7
SENP8_HUMAN Q96LD8 Sentrin-specific protease 8
SEPR_HUMAN Q12884 Prolyl endopeptidase FAP
SPP2A_HUMAN Q8TCT8 Signal peptide peptidase-like 2A ×
SPP2B_HUMAN Q8TCT7 Signal peptide peptidase-like 2B ×
ST14_HUMAN Q9Y5Y6 Suppressor of tumorigenicity 14 protein
STABP_HUMAN O95630 STAM-binding protein ×
TASP1_HUMAN Q9H6P5 Threonine aspartase 1
THRB_HUMAN P00734 Prothrombin
TM11D_HUMAN O60235 Transmembrane protease serine 11D
TMPS2_HUMAN O15393 Transmembrane protease serine 2
TMPS4_HUMAN Q9NRS4 Transmembrane protease serine 4
TMPS6_HUMAN Q8IU80 Transmembrane protease serine 6
TPA_HUMAN P00750 Tissue-type plasminogen activator
TPP2_HUMAN P29144 Tripeptidyl-peptidase 2
TRHDE_HUMAN Q9UKU6 Thyrotropin-releasing hormone-degrading ectoenzyme ×
TRY1_HUMAN P07477 Trypsin-1
TRY2_HUMAN P07478 Trypsin-2
TRY3_HUMAN P35030 Trypsin-3
TRYB1_HUMAN Q15661 Tryptase alpha/beta-1
TRYD_HUMAN Q9BZJ3 Tryptase delta
TRYG1_HUMAN Q9NRR2 Tryptase gamma
UBP1_HUMAN O94782 Ubiquitin carboxyl-terminal hydrolase 1
UBP10_HUMAN Q14694 Ubiquitin carboxyl-terminal hydrolase 10
UBP13_HUMAN Q92995 Ubiquitin carboxyl-terminal hydrolase 13
UBP14_HUMAN P54578 Ubiquitin carboxyl-terminal hydrolase 14
UBP18_HUMAN Q9UMW8 Ubl carboxyl-terminal hydrolase 18
UBP2_HUMAN O75604 Ubiquitin carboxyl-terminal hydrolase 2
UBP21_HUMAN Q9UK80 Ubiquitin carboxyl-terminal hydrolase 21
UBP4_HUMAN Q13107 Ubiquitin carboxyl-terminal hydrolase 4
UBP47_HUMAN Q96K76 Ubiquitin carboxyl-terminal hydrolase 47
UBP5_HUMAN P45974 Ubiquitin carboxyl-terminal hydrolase 5
UBP7_HUMAN Q93009 Ubiquitin carboxyl-terminal hydrolase 7
UCHL1_HUMAN P09936 Ubiquitin carboxyl-terminal hydrolase isozyme L1
UCHL3_HUMAN P15374 Ubiquitin carboxyl-terminal hydrolase isozyme L3
UCHL5_HUMAN Q9Y5K5 Ubiquitin carboxyl-terminal hydrolase isozyme L5
UROK_HUMAN P00749 Urokinase-type plasminogen activator
USP9X_HUMAN Q93008 Probable ubiquitin carboxyl-terminal hydrolase FAF-X
XPP1_HUMAN Q9NQW7 Xaa-Pro aminopeptidase 1
XPP2_HUMAN O43895 Xaa-Pro aminopeptidase 2
Total target proteins: 203 220

2020年3月公開