CGBVS予測モデルタンパクリストGPCR

予測モデルを選択:

モデル情報:

STDHA
標的タンパク数263258
学習データ数186225190621
*STD = Standard Model, HA = High Activity Model

相互作用(リガンド)データ数 ◎:500~、○:100~499、△:1~99、x:0

UniProt IDAccessionProtein NameStandard ModelHigh Activity Model
FFAR3_HUMANO14843Free fatty acid receptor 3
5HT1A_HUMANP089085-hydroxytryptamine receptor 1A
5HT1B_HUMANP282225-hydroxytryptamine receptor 1B
5HT1D_HUMANP282215-hydroxytryptamine receptor 1D
5HT1E_HUMANP285665-hydroxytryptamine receptor 1E
5HT1F_HUMANP309395-hydroxytryptamine receptor 1F
5HT2A_HUMANP282235-hydroxytryptamine receptor 2A
5HT2B_HUMANP415955-hydroxytryptamine receptor 2B
5HT2C_HUMANP283355-hydroxytryptamine receptor 2C
5HT4R_HUMANQ136395-hydroxytryptamine receptor 4
5HT5A_HUMANP478985-hydroxytryptamine receptor 5A
5HT6R_HUMANP504065-hydroxytryptamine receptor 6
5HT7R_HUMANP349695-hydroxytryptamine receptor 7
AA1R_HUMANP30542Adenosine receptor A1
AA2AR_HUMANP29274Adenosine receptor A2a
AA2BR_HUMANP29275Adenosine receptor A2b
AA3R_HUMANP0DMS8Adenosine receptor A3
ACKR3_HUMANP25106Atypical chemokine receptor 3
ACM1_HUMANP11229Muscarinic acetylcholine receptor M1
ACM2_HUMANP08172Muscarinic acetylcholine receptor M2
ACM3_HUMANP20309Muscarinic acetylcholine receptor M3
ACM4_HUMANP08173Muscarinic acetylcholine receptor M4
ACM5_HUMANP08912Muscarinic acetylcholine receptor M5
ADA1A_HUMANP35348Alpha-1A adrenergic receptor
ADA1B_HUMANP35368Alpha-1B adrenergic receptor
ADA1D_HUMANP25100Alpha-1D adrenergic receptor
ADA2A_HUMANP08913Alpha-2A adrenergic receptor
ADA2B_HUMANP18089Alpha-2B adrenergic receptor
ADA2C_HUMANP18825Alpha-2C adrenergic receptor
ADRB1_HUMANP08588Beta-1 adrenergic receptor
ADRB2_HUMANP07550Beta-2 adrenergic receptor
ADRB3_HUMANP13945Beta-3 adrenergic receptor
AGTR1_HUMANP30556Type-1 angiotensin II receptor
AGTR2_HUMANP50052Type-2 angiotensin II receptor
APJ_HUMANP35414Apelin receptor
BKRB1_HUMANP46663B1 bradykinin receptor
BKRB2_HUMANP30411B2 bradykinin receptor
BRS3_HUMANP32247Bombesin receptor subtype-3
C3AR_HUMANQ16581C3a anaphylatoxin chemotactic receptor
C5AR1_HUMANP21730C5a anaphylatoxin chemotactic receptor 1
C5AR2_HUMANQ9P296C5a anaphylatoxin chemotactic receptor 2×
CALCR_HUMANP30988Calcitonin receptor
CALRL_HUMANQ16602Calcitonin gene-related peptide type 1 receptor
CASR_HUMANP41180Extracellular calcium-sensing receptor
CCKAR_HUMANP32238Cholecystokinin receptor type A
CCR10_HUMANP46092C-C chemokine receptor type 10
CCR1_HUMANP32246C-C chemokine receptor type 1
CCR2_HUMANP41597C-C chemokine receptor type 2
CCR3_HUMANP51677C-C chemokine receptor type 3
CCR4_HUMANP51679C-C chemokine receptor type 4
CCR5_HUMANP51681C-C chemokine receptor type 5
CCR6_HUMANP51684C-C chemokine receptor type 6
CCR7_HUMANP32248C-C chemokine receptor type 7
CCR8_HUMANP51685C-C chemokine receptor type 8
CCR9_HUMANP51686C-C chemokine receptor type 9
CCRL2_HUMANO00421C-C chemokine receptor-like 2
CLTR1_HUMANQ9Y271Cysteinyl leukotriene receptor 1
CLTR2_HUMANQ9NS75Cysteinyl leukotriene receptor 2
CML1_HUMANQ99788Chemerin-like receptor 1
CNR1_HUMANP21554Cannabinoid receptor 1
CNR2_HUMANP34972Cannabinoid receptor 2
CRFR1_HUMANP34998Corticotropin-releasing factor receptor 1
CRFR2_HUMANQ13324Corticotropin-releasing factor receptor 2
CX3C1_HUMANP49238CX3C chemokine receptor 1
CXCR1_HUMANP25024C-X-C chemokine receptor type 1
CXCR2_HUMANP25025C-X-C chemokine receptor type 2
CXCR3_HUMANP49682C-X-C chemokine receptor type 3
CXCR4_HUMANP61073C-X-C chemokine receptor type 4
CXCR5_HUMANP32302C-X-C chemokine receptor type 5
CXCR6_HUMANO00574C-X-C chemokine receptor type 6
DRD1_HUMANP21728D(1A) dopamine receptor
DRD2_HUMANP14416D(2) dopamine receptor
DRD3_HUMANP35462D(3) dopamine receptor
DRD4_HUMANP21917D(4) dopamine receptor
DRD5_HUMANP21918D(1B) dopamine receptor
EDNRA_HUMANP25101Endothelin-1 receptor
EDNRB_HUMANP24530Endothelin receptor type B
FFAR1_HUMANO14842Free fatty acid receptor 1
FFAR2_HUMANO15552Free fatty acid receptor 2
FFAR4_HUMANQ5NUL3Free fatty acid receptor 4
FPR1_HUMANP21462fMet-Leu-Phe receptor
FPR2_HUMANP25090N-formyl peptide receptor 2
FSHR_HUMANP23945Follicle-stimulating hormone receptor
GABR1_HUMANQ9UBS5Gamma-aminobutyric acid type B receptor subunit 1
GABR2_HUMANO75899Gamma-aminobutyric acid type B receptor subunit 2
GALR1_HUMANP47211Galanin receptor type 1
GALR2_HUMANO43603Galanin receptor type 2
GALR3_HUMANO60755Galanin receptor type 3
GASR_HUMANP32239Gastrin/cholecystokinin type B receptor
GHRHR_HUMANQ02643Growth hormone-releasing hormone receptor
GHSR_HUMANQ92847Growth hormone secretagogue receptor type 1
GIPR_HUMANP48546Gastric inhibitory polypeptide receptor
GLP1R_HUMANP43220Glucagon-like peptide 1 receptor
GLR_HUMANP47871Glucagon receptor
GNRHR_HUMANP30968Gonadotropin-releasing hormone receptor
GP119_HUMANQ8TDV5Glucose-dependent insulinotropic receptor
GP139_HUMANQ6DWJ6Probable G-protein coupled receptor 139
GP142_HUMANQ7Z601Probable G-protein coupled receptor 142
GP174_HUMANQ9BXC1Probable G-protein coupled receptor 174
GP183_HUMANP32249G-protein coupled receptor 183
GPBAR_HUMANQ8TDU6G-protein coupled bile acid receptor 1
GPER1_HUMANQ99527G-protein coupled estrogen receptor 1
GPR15_HUMANP49685G-protein coupled receptor 15
GPR17_HUMANQ13304Uracil nucleotide/cysteinyl leukotriene receptor
GPR18_HUMANQ14330N-arachidonyl glycine receptor
GPR27_HUMANQ9NS67Probable G-protein coupled receptor 27
GPR34_HUMANQ9UPC5Probable G-protein coupled receptor 34
GPR35_HUMANQ9HC97G-protein coupled receptor 35
GPR39_HUMANO43194G-protein coupled receptor 39
GPR4_HUMANP46093G-protein coupled receptor 4
GPR52_HUMANQ9Y2T5G-protein coupled receptor 52
GPR55_HUMANQ9Y2T6G-protein coupled receptor 55
GPR6_HUMANP46095G-protein coupled receptor 6
GPR84_HUMANQ9NQS5G-protein coupled receptor 84
GPR88_HUMANQ9GZN0Probable G-protein coupled receptor 88
GRM1_HUMANQ13255Metabotropic glutamate receptor 1
GRM2_HUMANQ14416Metabotropic glutamate receptor 2
GRM3_HUMANQ14832Metabotropic glutamate receptor 3
GRM4_HUMANQ14833Metabotropic glutamate receptor 4
GRM5_HUMANP41594Metabotropic glutamate receptor 5
GRM6_HUMANO15303Metabotropic glutamate receptor 6
GRM7_HUMANQ14831Metabotropic glutamate receptor 7
GRM8_HUMANO00222Metabotropic glutamate receptor 8
GRPR_HUMANP30550Gastrin-releasing peptide receptor
HCAR1_HUMANQ9BXC0Hydroxycarboxylic acid receptor 1
HCAR2_HUMANQ8TDS4Hydroxycarboxylic acid receptor 2
HCAR3_HUMANP49019Hydroxycarboxylic acid receptor 3
HRH1_HUMANP35367Histamine H1 receptor
HRH2_HUMANP25021Histamine H2 receptor
HRH3_HUMANQ9Y5N1Histamine H3 receptor
HRH4_HUMANQ9H3N8Histamine H4 receptor
KISSR_HUMANQ969F8KiSS-1 receptor
LPAR1_HUMANQ92633Lysophosphatidic acid receptor 1
LPAR2_HUMANQ9HBW0Lysophosphatidic acid receptor 2
LPAR3_HUMANQ9UBY5Lysophosphatidic acid receptor 3
LPAR4_HUMANQ99677Lysophosphatidic acid receptor 4
LPAR5_HUMANQ9H1C0Lysophosphatidic acid receptor 5
LPAR6_HUMANP43657Lysophosphatidic acid receptor 6
LSHR_HUMANP22888Lutropin-choriogonadotropic hormone receptor
LT4R1_HUMANQ15722Leukotriene B4 receptor 1
LT4R2_HUMANQ9NPC1Leukotriene B4 receptor 2
MAS_HUMANP04201Proto-oncogene Mas
MC3R_HUMANP41968Melanocortin receptor 3
MC4R_HUMANP32245Melanocortin receptor 4
MC5R_HUMANP33032Melanocortin receptor 5
MCHR1_HUMANQ99705Melanin-concentrating hormone receptor 1
MCHR2_HUMANQ969V1Melanin-concentrating hormone receptor 2
MRGX1_HUMANQ96LB2Mas-related G-protein coupled receptor member X1
MRGX2_HUMANQ96LB1Mas-related G-protein coupled receptor member X2
MRGX4_HUMANQ96LA9Mas-related G-protein coupled receptor member X4
MSHR_HUMANQ01726Melanocyte-stimulating hormone receptor
MTLR_HUMANO43193Motilin receptor
MTR1A_HUMANP48039Melatonin receptor type 1A
MTR1B_HUMANP49286Melatonin receptor type 1B
NK1R_HUMANP25103Substance-P receptor
NK2R_HUMANP21452Substance-K receptor
NK3R_HUMANP29371Neuromedin-K receptor
NMBR_HUMANP28336Neuromedin-B receptor
NMUR1_HUMANQ9HB89Neuromedin-U receptor 1
NMUR2_HUMANQ9GZQ4Neuromedin-U receptor 2
NPBW1_HUMANP48145Neuropeptides B/W receptor type 1
NPFF1_HUMANQ9GZQ6Neuropeptide FF receptor 1
NPFF2_HUMANQ9Y5X5Neuropeptide FF receptor 2
NPSR1_HUMANQ6W5P4Neuropeptide S receptor
NPY1R_HUMANP25929Neuropeptide Y receptor type 1
NPY2R_HUMANP49146Neuropeptide Y receptor type 2
NPY4R_HUMANP50391Neuropeptide Y receptor type 4
NPY5R_HUMANQ15761Neuropeptide Y receptor type 5
NTR1_HUMANP30989Neurotensin receptor type 1
NTR2_HUMANO95665Neurotensin receptor type 2
O51E2_HUMANQ9H255Olfactory receptor 51E2
OGR1_HUMANQ15743Ovarian cancer G-protein coupled receptor 1
OPRD_HUMANP41143Delta-type opioid receptor
OPRK_HUMANP41145Kappa-type opioid receptor
OPRM_HUMANP35372Mu-type opioid receptor
OPRX_HUMANP41146Nociceptin receptor
OX1R_HUMANO43613Orexin/Hypocretin receptor type 1
OX2R_HUMANO43614Orexin receptor type 2
OXER1_HUMANQ8TDS5Oxoeicosanoid receptor 1
OXGR1_HUMANQ96P682-oxoglutarate receptor 1×
OXYR_HUMANP30559Oxytocin receptor
P2RY1_HUMANP47900P2Y purinoceptor 1
P2RY2_HUMANP41231P2Y purinoceptor 2
P2RY4_HUMANP51582P2Y purinoceptor 4
P2RY6_HUMANQ15077P2Y purinoceptor 6
P2Y10_HUMANO00398Putative P2Y purinoceptor 10
P2Y11_HUMANQ96G91P2Y purinoceptor 11
P2Y12_HUMANQ9H244P2Y purinoceptor 12
P2Y14_HUMANQ15391P2Y purinoceptor 14
PACR_HUMANP41586Pituitary adenylate cyclase-activating polypeptide type I re
PAR1_HUMANP25116Proteinase-activated receptor 1
PAR2_HUMANP55085Proteinase-activated receptor 2
PAR4_HUMANQ96RI0Proteinase-activated receptor 4
PD2R2_HUMANQ9Y5Y4Prostaglandin D2 receptor 2
PD2R_HUMANQ13258Prostaglandin D2 receptor
PE2R1_HUMANP34995Prostaglandin E2 receptor EP1 subtype
PE2R2_HUMANP43116Prostaglandin E2 receptor EP2 subtype
PE2R3_HUMANP43115Prostaglandin E2 receptor EP3 subtype
PE2R4_HUMANP35408Prostaglandin E2 receptor EP4 subtype
PF2R_HUMANP43088Prostaglandin F2-alpha receptor
PI2R_HUMANP43119Prostacyclin receptor
PKR1_HUMANQ8TCW9Prokineticin receptor 1
PKR2_HUMANQ8NFJ6Prokineticin receptor 2×
PRLHR_HUMANP49683Prolactin-releasing peptide receptor
PTAFR_HUMANP25105Platelet-activating factor receptor
PTH1R_HUMANQ03431Parathyroid hormone/parathyroid hormone-related peptide rece
QRFPR_HUMANQ96P65Pyroglutamylated RF-amide peptide receptor
RL3R1_HUMANQ9NSD7Relaxin-3 receptor 1
RL3R2_HUMANQ8TDU9Relaxin-3 receptor 2
RXFP1_HUMANQ9HBX9Relaxin receptor 1
RXFP2_HUMANQ8WXD0Relaxin receptor 2
S1PR1_HUMANP21453Sphingosine 1-phosphate receptor 1
S1PR2_HUMANO95136Sphingosine 1-phosphate receptor 2
S1PR3_HUMANQ99500Sphingosine 1-phosphate receptor 3
S1PR4_HUMANO95977Sphingosine 1-phosphate receptor 4
S1PR5_HUMANQ9H228Sphingosine 1-phosphate receptor 5
SMO_HUMANQ99835Protein smoothened
SSR1_HUMANP30872Somatostatin receptor type 1
SSR2_HUMANP30874Somatostatin receptor type 2
SSR3_HUMANP32745Somatostatin receptor type 3
SSR4_HUMANP31391Somatostatin receptor type 4
SSR5_HUMANP35346Somatostatin receptor type 5
SUCR1_HUMANQ9BXA5Succinate receptor 1
T2R10_HUMANQ9NYW0Taste receptor type 2 member 10
T2R13_HUMANQ9NYV9Taste receptor type 2 member 13
T2R14_HUMANQ9NYV8Taste receptor type 2 member 14
T2R16_HUMANQ9NYV7Taste receptor type 2 member 16
T2R19_HUMANP59542Taste receptor type 2 member 19
T2R20_HUMANP59543Taste receptor type 2 member 20
T2R30_HUMANP59541Taste receptor type 2 member 30
T2R31_HUMANP59538Taste receptor type 2 member 31
T2R38_HUMANP59533Taste receptor type 2 member 38
T2R39_HUMANP59534Taste receptor type 2 member 39
T2R40_HUMANP59535Taste receptor type 2 member 40
T2R41_HUMANP59536Taste receptor type 2 member 41
T2R42_HUMANQ7RTR8Taste receptor type 2 member 42
T2R43_HUMANP59537Taste receptor type 2 member 43
T2R45_HUMANP59539Taste receptor type 2 member 45
T2R46_HUMANP59540Taste receptor type 2 member 46
T2R50_HUMANP59544Taste receptor type 2 member 50
T2R60_HUMANP59551Taste receptor type 2 member 60
TA2R1_HUMANQ9NYW7Taste receptor type 2 member 1
TA2R3_HUMANQ9NYW6Taste receptor type 2 member 3
TA2R4_HUMANQ9NYW5Taste receptor type 2 member 4
TA2R5_HUMANQ9NYW4Taste receptor type 2 member 5
TA2R7_HUMANQ9NYW3Taste receptor type 2 member 7
TA2R8_HUMANQ9NYW2Taste receptor type 2 member 8
TA2R9_HUMANQ9NYW1Taste receptor type 2 member 9
TA2R_HUMANP21731Thromboxane A2 receptor
TAAR1_HUMANQ96RJ0Trace amine-associated receptor 1
TAAR5_HUMANO14804Trace amine-associated receptor 5×
TRFR_HUMANP34981Thyrotropin-releasing hormone receptor
TS1R1_HUMANQ7RTX1Taste receptor type 1 member 1
TS1R2_HUMANQ8TE23Taste receptor type 1 member 2
TS1R3_HUMANQ7RTX0Taste receptor type 1 member 3
TSHR_HUMANP16473Thyrotropin receptor
UR2R_HUMANQ9UKP6Urotensin-2 receptor
V1AR_HUMANP37288Vasopressin V1a receptor
V1BR_HUMANP47901Vasopressin V1b receptor
V2R_HUMANP30518Vasopressin V2 receptor
VIPR1_HUMANP32241Vasoactive intestinal polypeptide receptor 1
VIPR2_HUMANP41587Vasoactive intestinal polypeptide receptor 2
P2Y13_HUMANQ9BPV8P2Y purinoceptor 13×
Total target proteins:263258

CGBVSでAUROCが0.7以上を期待できるオーファンターゲット(※ ChEMBL27モデルによるデータです)

UniProt IDAccessionProtein Name
GPR42_HUMANO15529G-protein coupled receptor 42
GPR32_HUMANO75388Probable G-protein coupled receptor 32
GPR1_HUMANP46091G-protein coupled receptor 1
CXCR6_HUMANO00574C-X-C chemokine receptor type 6
ACKR4_HUMANQ9NPB9Atypical chemokine receptor 4
T2R20_HUMANP59543Taste receptor type 2 member 20
T2R50_HUMANP59544Taste receptor type 2 member 50
T2R45_HUMANP59539Taste receptor type 2 member 45
T2R30_HUMANP59541Taste receptor type 2 member 30
OGR1_HUMANQ15743Ovarian cancer G-protein coupled receptor 1
T2R43_HUMANP59537Taste receptor type 2 member 43
GPR21_HUMANQ99679Probable G-protein coupled receptor 21
T2R46_HUMANP59540Taste receptor type 2 member 46
TA2R3_HUMANQ9NYW6Taste receptor type 2 member 3
XCR1_HUMANP46094Chemokine XC receptor 1
T2R19_HUMANP59542Taste receptor type 2 member 19
MRGX3_HUMANQ96LB0Mas-related G-protein coupled receptor member X3
MRGX4_HUMANQ96LA9Mas-related G-protein coupled receptor member X4
TAAR8_HUMANQ969N4Trace amine-associated receptor 8
T2R13_HUMANQ9NYV9Taste receptor type 2 member 13
ACKR2_HUMANO00590Atypical chemokine receptor 2
TAAR6_HUMANQ96RI8Trace amine-associated receptor 6
TAAR9_HUMANQ96RI9Trace amine-associated receptor 9
GPR87_HUMANQ9BY21G-protein coupled receptor 87
TA2R9_HUMANQ9NYW1Taste receptor type 2 member 9
TA2R7_HUMANQ9NYW3Taste receptor type 2 member 7
TAAR3_HUMANQ9P1P4Putative trace amine-associated receptor 3
GPR12_HUMANP47775G-protein coupled receptor 12
GPR3_HUMANP46089G-protein coupled receptor 3
TAAR2_HUMANQ9P1P5Trace amine-associated receptor 2
NPY6R_HUMANQ99463Putative neuropeptide Y receptor type 6
P2Y13_HUMANQ9BPV8P2Y purinoceptor 13
FPR3_HUMANP25089N-formyl peptide receptor 3
NPBW2_HUMANP48146Neuropeptides B/W receptor type 2
MTR1L_HUMANQ13585Melatonin-related receptor
ACTHR_HUMANQ01718Adrenocorticotropic hormone receptor
SCTR_HUMANP47872Secretin receptor
PTH2R_HUMANP49190Parathyroid hormone 2 receptor
GLP2R_HUMANO95838Glucagon-like peptide 2 receptor
Total target proteins: 39

関連文献:
Kanai, C., Kawasaki, E., Murakami, R., Morita, Y., & Yoshimori, A. (2021). Computational Prediction of Compound–Protein Interactions for Orphan Targets Using CGBVS. Molecules, 26(17), 5131. (https://doi.org/10.3390/molecules26175131)

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