{"id":2778,"date":"2025-09-16T22:36:16","date_gmt":"2025-09-16T13:36:16","guid":{"rendered":"https:\/\/www.insilico.jp\/blog\/?p=2778"},"modified":"2025-09-25T17:51:26","modified_gmt":"2025-09-25T08:51:26","slug":"core_embed_docking","status":"publish","type":"post","link":"https:\/\/www.insilico.jp\/blog\/2025\/09\/16\/core_embed_docking\/","title":{"rendered":"\u9aa8\u683c\u306e\u7acb\u4f53\u914d\u5ea7\u306e\u56fa\u5b9a\u3068\u30c9\u30c3\u30ad\u30f3\u30b0"},"content":{"rendered":"\n

\u7406\u8ad6\u5275\u85ac\u7814\u7a76\u6240\u306e\u5409\u68ee\u3067\u3059\u3002
\u30aa\u30fc\u30d7\u30f3\u30bd\u30fc\u30b9\u306e\u30c9\u30c3\u30ad\u30f3\u30b0\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u306e\u591a\u304f\u306f\u3001\u74b0\u69cb\u9020\u306b\u304a\u3051\u308b\u30a4\u30b9\u5f62\u3068\u821f\u5f62\u306a\u3069\u306e\u5909\u5316\u3092\u8003\u616e\u3067\u304d\u306a\u3044\u305f\u3081\u3001\u521d\u671f\u914d\u5ea7\u304c\u30c9\u30c3\u30ad\u30f3\u30b0\u306e\u7d50\u679c\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u304c\u5927\u304d\u3044\u3068\u601d\u3044\u307e\u3059\u3002\u4eca\u56de\u306f\u3001\u307e\u305a\u306f\u9aa8\u683c\u306e\u7acb\u4f53\u914d\u5ea7\u3092\u56fa\u5b9a\u3057\u305f\u72b6\u614b\u3067\u5074\u9396\u306e\u7acb\u4f53\u914d\u5ea7\u3092\u751f\u6210\u3055\u305b\u3001\u5206\u5b50\u306e\u7acb\u4f53\u914d\u5ea7\u3092\u751f\u6210\u3057\u307e\u3059\u3002\u6b21\u306b\u3001\u305d\u306e\u7acb\u4f53\u914d\u5ea7\u3092\u7528\u3044\u3066\u30c9\u30c3\u30ad\u30f3\u30b0\u3092\u884c\u3044\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u9aa8\u683c\u306e\u7acb\u4f53\u914d\u5ea7\u3092\u56fa\u5b9a\u3057\u305f\u521d\u671f\u914d\u5ea7\u306e\u751f\u6210<\/h3>\n\n\n\n

\u4e0b\u56f3\u306fXIAP\u3068\u963b\u5bb3\u5264\u306e\u7d50\u6676\u69cb\u9020(PDB:5OQW)\u3067\u3059\u304c\u3001\u9aa8\u683c\uff08\u70ad\u7d20\uff1a\u7070\u8272\uff09\u306e\u7acb\u4f53\u914d\u5ea7\u3092\u56fa\u5b9a\u3057\u3066\u3001\u5074\u9396\uff08\u70ad\u7d20\uff1a\u9ec4\u8272\uff09\u306e\u914d\u5ea7\u751f\u6210\u3092\u884c\u3044\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

RDKit\u306e”AllChem.ConstrainedEmbed”\u3092\u5229\u7528\u3059\u308b\u3053\u3068\u3067\u5b9f\u73fe\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n

core_embedded.py\uff1a<\/strong><\/p>\n\n\n\n

from rdkit.Chem import AllChem\nimport argparse\n\nparser = argparse.ArgumentParser(description=\"core_embedded.py\")\nparser.add_argument(\"input1\", help=\"mol of core structure\")\nparser.add_argument(\"input2\", help=\"smiles of molecules\")\nparser.add_argument(\"output\", help=\"sdf of molecules\")\n\ndef main():\n    args = parser.parse_args()\n    core_file = args.input1\n    smi_file = args.input2\n    out_file = args.output\n    \n    core = Chem.MolFromMolFile(core_file)\n    mols = [Chem.AddHs(mol) for mol in Chem.SmilesMolSupplier(smi_file,delimiter='\\t',titleLine=0) if mol is not None]\n \n    fw = Chem.SDWriter(out_file)\n    for mol in mols:\n        try:\n            AllChem.ConstrainedEmbed(mol, core)\n            fw.write(mol)\n        except:\n            print(f\"{mol.GetProp('_Name')} doesn't have core structure\")\n    fw.close()\n\nif __name__ == '__main__':\n    main()<\/code><\/pre>\n\n\n\n
\u4e0a\u8a18\u306e\u30b9\u30af\u30ea\u30d7\u30c8\u3092\u4f7f\u3063\u3066\u914d\u5ea7\u751f\u6210\u3092\u884c\u3063\u3066\u307f\u307e\u3059\u3002
$ python core_embedded.py core.sdf test_cpds.smi test_cpds.sdf

\u3000core.sdf\uff1a\u56fa\u5b9a\u3057\u305f\u3044\u9aa8\u683c\u306e\u7acb\u4f53\u914d\u5ea7
\u3000test_cpds.smi\uff1a\u5206\u5b50\u306eSMILES(\u56fa\u5b9a\u3057\u305f\u3044\u9aa8\u683c\u3092\u90e8\u5206\u69cb\u9020\u3068\u3057\u3066\u542b\u3093\u3067\u3044\u308b\u3053\u3068)
\u3000test_cpds.sdf\uff1a\u9aa8\u683c\u306e\u7acb\u4f53\u914d\u5ea7\u304c\u56fa\u5b9a\u3055\u308c\u305f\u5206\u5b50\u306e\u7acb\u4f53\u914d\u5ea7\uff08\u51fa\u529b\u30d5\u30a1\u30a4\u30eb\uff09<\/p>\n\n\n\n
\"\"<\/figure>\n\n\n\n
\u751f\u6210\u3055\u308c\u305f\u7acb\u4f53\u914d\u5ea7\uff08\u70ad\u7d20\uff1a\u7dd1\uff09\u3092\u307f\u308b\u3068\u3001\u9aa8\u683c\u306f\u7d50\u6676\u69cb\u9020\u306e\u7acb\u4f53\u914d\u5ea7\uff08\u70ad\u7d20\uff1a\u7070\u8272\uff09\u3068\u540c\u3058\u3067\u3059\u304c\u3001\u5074\u9396\u306e\u7acb\u4f53\u914d\u5ea7\uff08\u70ad\u7d20\uff1a\u9ec4\u8272\uff09\u306f\u7570\u306a\u308b\u3053\u3068\u304c\u5206\u304b\u308b\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n\n\n\n
\u30c9\u30c3\u30ad\u30f3\u30b0<\/h2>\n\n\n\n
\u524d\u9805\u3067\u751f\u6210\u3057\u305f\u5206\u5b50\u306e\u7acb\u4f53\u914d\u5ea7\u3092\u7528\u3044\u3066GNINA<\/a>\u3092\u4f7f\u3063\u3066\u30c9\u30ad\u30f3\u30b0\u3092\u884c\u3044\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002
$ gnina -r 5OQW_receptor.pdb -l test_cpds.sdf -o docked_test_cpds.sdf –autobox_ligand 5OQW_ligand.sdf –num_modes 1

 5OQW_receptor.pdb\uff1aXIAP\u306e\u69cb\u9020
 test_cpds.sdf\uff1a\u524d\u9805\u3067\u751f\u6210\u3057\u305f\u5206\u5b50\u306e\u7acb\u4f53\u914d\u5ea7
 docked_test_cpds.sdf\uff1a\u30c9\u30c3\u30ad\u30f3\u30b0\u306b\u3088\u308a\u5f97\u3089\u308c\u305f\u5206\u5b50\u306e\u7d50\u5408\u914d\u5ea7
 5OQW_ligand.sdf\uff1a\u7d50\u6676\u69cb\u9020\u306b\u542b\u307e\u308c\u3066\u3044\u308b\u963b\u5bb3\u5264\u306e\u7acb\u4f53\u914d\u5ea7<\/p>\n\n\n\n
\"\"<\/figure>\n\n\n\n
\u30c9\u30c3\u30ad\u30f3\u30b0\u306b\u3088\u308b\u4e88\u6e2c\u914d\u5ea7\uff08\u70ad\u7d20\uff1a\u7dd1\uff09\u3092\u307f\u308b\u3068\u7d50\u6676\u69cb\u9020\uff08\u70ad\u7d20\uff1a\u7070\u8272 or \u9ec4\u8272\uff09\u3068\u3088\u304f\u91cd\u306a\u3063\u3066\u3044\u308b\u3068\u601d\u3044\u307e\u3059\u3002\u4eca\u56de\u306e\u624b\u9806\u3092\u7528\u3044\u3066\u3001\u5074\u9396\u69cb\u9020\u306e\u7570\u306a\u308b\u5206\u5b50\u3092\u8907\u6570\u767a\u751f\u3055\u305b\u3001\u30c9\u30c3\u30ad\u30f3\u30b0\u3092\u884c\u3046\u3053\u3068\u3067\u3001\u5074\u9396\u69cb\u9020\u306e\u6700\u9069\u5316\u306a\u3069\u306b\u5229\u7528\u3067\u304d\u308b\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"
\u7406\u8ad6\u5275\u85ac\u7814\u7a76\u6240\u306e\u5409\u68ee\u3067\u3059\u3002\u30aa\u30fc\u30d7\u30f3\u30bd\u30fc\u30b9\u306e\u30c9\u30c3\u30ad\u30f3\u30b0\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u306e\u591a\u304f\u306f\u3001\u74b0\u69cb\u9020\u306b\u304a\u3051\u308b\u30a4\u30b9\u5f62\u3068\u821f\u5f62\u306a\u3069\u306e\u5909\u5316\u3092\u8003\u616e\u3067\u304d\u306a\u3044\u305f\u3081\u3001\u521d\u671f\u914d\u5ea7\u304c\u30c9\u30c3\u30ad\u30f3\u30b0\u306e\u7d50\u679c\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u304c\u5927\u304d\u3044\u3068\u601d\u3044\u307e\u3059\u3002\u4eca\u56de\u306f\u3001\u307e\u305a\u306f\u9aa8\u683c\u306e\u7acb\u4f53\u914d\u5ea7\u3092\u56fa…<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[118,8],"tags":[],"class_list":["post-2778","post","type-post","status-publish","format-standard","hentry","category-ai-drug-discovery","category-docking"],"yoast_head":"\n\u9aa8\u683c\u306e\u7acb\u4f53\u914d\u5ea7\u306e\u56fa\u5b9a\u3068\u30c9\u30c3\u30ad\u30f3\u30b0 - In Silico \u5275\u85ac<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.insilico.jp\/blog\/2025\/09\/16\/core_embed_docking\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u9aa8\u683c\u306e\u7acb\u4f53\u914d\u5ea7\u306e\u56fa\u5b9a\u3068\u30c9\u30c3\u30ad\u30f3\u30b0 - In Silico \u5275\u85ac\" \/>\n<meta property=\"og:description\" content=\"\u7406\u8ad6\u5275\u85ac\u7814\u7a76\u6240\u306e\u5409\u68ee\u3067\u3059\u3002\u30aa\u30fc\u30d7\u30f3\u30bd\u30fc\u30b9\u306e\u30c9\u30c3\u30ad\u30f3\u30b0\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u306e\u591a\u304f\u306f\u3001\u74b0\u69cb\u9020\u306b\u304a\u3051\u308b\u30a4\u30b9\u5f62\u3068\u821f\u5f62\u306a\u3069\u306e\u5909\u5316\u3092\u8003\u616e\u3067\u304d\u306a\u3044\u305f\u3081\u3001\u521d\u671f\u914d\u5ea7\u304c\u30c9\u30c3\u30ad\u30f3\u30b0\u306e\u7d50\u679c\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u304c\u5927\u304d\u3044\u3068\u601d\u3044\u307e\u3059\u3002\u4eca\u56de\u306f\u3001\u307e\u305a\u306f\u9aa8\u683c\u306e\u7acb\u4f53\u914d\u5ea7\u3092\u56fa...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.insilico.jp\/blog\/2025\/09\/16\/core_embed_docking\/\" \/>\n<meta property=\"og:site_name\" content=\"In Silico \u5275\u85ac\" \/>\n<meta property=\"article:published_time\" content=\"2025-09-16T13:36:16+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-25T08:51:26+00:00\" \/>\n<meta name=\"author\" content=\"\u7406\u8ad6\u5275\u85ac\u7814\u7a76\u6240 \u5409\u68ee \u7be4\u53f2\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u57f7\u7b46\u8005\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u7406\u8ad6\u5275\u85ac\u7814\u7a76\u6240 \u5409\u68ee \u7be4\u53f2\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u63a8\u5b9a\u8aad\u307f\u53d6\u308a\u6642\u9593\" \/>\n\t<meta name=\"twitter:data2\" content=\"5\u5206\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.insilico.jp\/blog\/2025\/09\/16\/core_embed_docking\/\",\"url\":\"https:\/\/www.insilico.jp\/blog\/2025\/09\/16\/core_embed_docking\/\",\"name\":\"\u9aa8\u683c\u306e\u7acb\u4f53\u914d\u5ea7\u306e\u56fa\u5b9a\u3068\u30c9\u30c3\u30ad\u30f3\u30b0 - In Silico \u5275\u85ac\",\"isPartOf\":{\"@id\":\"https:\/\/www.insilico.jp\/blog\/#website\"},\"datePublished\":\"2025-09-16T13:36:16+00:00\",\"dateModified\":\"2025-09-25T08:51:26+00:00\",\"author\":{\"@id\":\"https:\/\/www.insilico.jp\/blog\/#\/schema\/person\/664c52818e6b55f18a964a18bd3932e0\"},\"breadcrumb\":{\"@id\":\"https:\/\/www.insilico.jp\/blog\/2025\/09\/16\/core_embed_docking\/#breadcrumb\"},\"inLanguage\":\"ja\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.insilico.jp\/blog\/2025\/09\/16\/core_embed_docking\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.insilico.jp\/blog\/2025\/09\/16\/core_embed_docking\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u30db\u30fc\u30e0\",\"item\":\"https:\/\/www.insilico.jp\/blog\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u9aa8\u683c\u306e\u7acb\u4f53\u914d\u5ea7\u306e\u56fa\u5b9a\u3068\u30c9\u30c3\u30ad\u30f3\u30b0\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.insilico.jp\/blog\/#website\",\"url\":\"https:\/\/www.insilico.jp\/blog\/\",\"name\":\"In Silico \u5275\u85ac\",\"description\":\"\u3053\u306e\u30d6\u30ed\u30b0\u30b5\u30a4\u30c8\u306f\u3001In silico\u5275\u85ac\u306b\u95a2\u9023\u3059\u308b\u7814\u7a76\u8ad6\u6587\u3084\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u30fb\u30c4\u30fc\u30eb\u306e\u5229\u7528\u3084\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0\u306a\u3069\u306b\u3064\u3044\u3066\u3054\u7d39\u4ecb\u3057\u3066\u3044\u307e\u3059\u3002\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.insilico.jp\/blog\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"ja\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.insilico.jp\/blog\/#\/schema\/person\/664c52818e6b55f18a964a18bd3932e0\",\"name\":\"\u7406\u8ad6\u5275\u85ac\u7814\u7a76\u6240 \u5409\u68ee \u7be4\u53f2\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ja\",\"@id\":\"https:\/\/www.insilico.jp\/blog\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/51254a747e245d5c8ba293a12e60d8d9?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/51254a747e245d5c8ba293a12e60d8d9?s=96&d=mm&r=g\",\"caption\":\"\u7406\u8ad6\u5275\u85ac\u7814\u7a76\u6240 \u5409\u68ee \u7be4\u53f2\"},\"url\":\"https:\/\/www.insilico.jp\/blog\/author\/yoshimori\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u9aa8\u683c\u306e\u7acb\u4f53\u914d\u5ea7\u306e\u56fa\u5b9a\u3068\u30c9\u30c3\u30ad\u30f3\u30b0 - In Silico \u5275\u85ac","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.insilico.jp\/blog\/2025\/09\/16\/core_embed_docking\/","og_locale":"ja_JP","og_type":"article","og_title":"\u9aa8\u683c\u306e\u7acb\u4f53\u914d\u5ea7\u306e\u56fa\u5b9a\u3068\u30c9\u30c3\u30ad\u30f3\u30b0 - In Silico \u5275\u85ac","og_description":"\u7406\u8ad6\u5275\u85ac\u7814\u7a76\u6240\u306e\u5409\u68ee\u3067\u3059\u3002\u30aa\u30fc\u30d7\u30f3\u30bd\u30fc\u30b9\u306e\u30c9\u30c3\u30ad\u30f3\u30b0\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u306e\u591a\u304f\u306f\u3001\u74b0\u69cb\u9020\u306b\u304a\u3051\u308b\u30a4\u30b9\u5f62\u3068\u821f\u5f62\u306a\u3069\u306e\u5909\u5316\u3092\u8003\u616e\u3067\u304d\u306a\u3044\u305f\u3081\u3001\u521d\u671f\u914d\u5ea7\u304c\u30c9\u30c3\u30ad\u30f3\u30b0\u306e\u7d50\u679c\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u304c\u5927\u304d\u3044\u3068\u601d\u3044\u307e\u3059\u3002\u4eca\u56de\u306f\u3001\u307e\u305a\u306f\u9aa8\u683c\u306e\u7acb\u4f53\u914d\u5ea7\u3092\u56fa...","og_url":"https:\/\/www.insilico.jp\/blog\/2025\/09\/16\/core_embed_docking\/","og_site_name":"In Silico \u5275\u85ac","article_published_time":"2025-09-16T13:36:16+00:00","article_modified_time":"2025-09-25T08:51:26+00:00","author":"\u7406\u8ad6\u5275\u85ac\u7814\u7a76\u6240 \u5409\u68ee \u7be4\u53f2","twitter_card":"summary_large_image","twitter_misc":{"\u57f7\u7b46\u8005":"\u7406\u8ad6\u5275\u85ac\u7814\u7a76\u6240 \u5409\u68ee \u7be4\u53f2","\u63a8\u5b9a\u8aad\u307f\u53d6\u308a\u6642\u9593":"5\u5206"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.insilico.jp\/blog\/2025\/09\/16\/core_embed_docking\/","url":"https:\/\/www.insilico.jp\/blog\/2025\/09\/16\/core_embed_docking\/","name":"\u9aa8\u683c\u306e\u7acb\u4f53\u914d\u5ea7\u306e\u56fa\u5b9a\u3068\u30c9\u30c3\u30ad\u30f3\u30b0 - In Silico \u5275\u85ac","isPartOf":{"@id":"https:\/\/www.insilico.jp\/blog\/#website"},"datePublished":"2025-09-16T13:36:16+00:00","dateModified":"2025-09-25T08:51:26+00:00","author":{"@id":"https:\/\/www.insilico.jp\/blog\/#\/schema\/person\/664c52818e6b55f18a964a18bd3932e0"},"breadcrumb":{"@id":"https:\/\/www.insilico.jp\/blog\/2025\/09\/16\/core_embed_docking\/#breadcrumb"},"inLanguage":"ja","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.insilico.jp\/blog\/2025\/09\/16\/core_embed_docking\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.insilico.jp\/blog\/2025\/09\/16\/core_embed_docking\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u30db\u30fc\u30e0","item":"https:\/\/www.insilico.jp\/blog\/"},{"@type":"ListItem","position":2,"name":"\u9aa8\u683c\u306e\u7acb\u4f53\u914d\u5ea7\u306e\u56fa\u5b9a\u3068\u30c9\u30c3\u30ad\u30f3\u30b0"}]},{"@type":"WebSite","@id":"https:\/\/www.insilico.jp\/blog\/#website","url":"https:\/\/www.insilico.jp\/blog\/","name":"In Silico \u5275\u85ac","description":"\u3053\u306e\u30d6\u30ed\u30b0\u30b5\u30a4\u30c8\u306f\u3001In silico\u5275\u85ac\u306b\u95a2\u9023\u3059\u308b\u7814\u7a76\u8ad6\u6587\u3084\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u30fb\u30c4\u30fc\u30eb\u306e\u5229\u7528\u3084\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0\u306a\u3069\u306b\u3064\u3044\u3066\u3054\u7d39\u4ecb\u3057\u3066\u3044\u307e\u3059\u3002","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.insilico.jp\/blog\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"ja"},{"@type":"Person","@id":"https:\/\/www.insilico.jp\/blog\/#\/schema\/person\/664c52818e6b55f18a964a18bd3932e0","name":"\u7406\u8ad6\u5275\u85ac\u7814\u7a76\u6240 \u5409\u68ee \u7be4\u53f2","image":{"@type":"ImageObject","inLanguage":"ja","@id":"https:\/\/www.insilico.jp\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/51254a747e245d5c8ba293a12e60d8d9?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/51254a747e245d5c8ba293a12e60d8d9?s=96&d=mm&r=g","caption":"\u7406\u8ad6\u5275\u85ac\u7814\u7a76\u6240 \u5409\u68ee \u7be4\u53f2"},"url":"https:\/\/www.insilico.jp\/blog\/author\/yoshimori\/"}]}},"_links":{"self":[{"href":"https:\/\/www.insilico.jp\/blog\/wp-json\/wp\/v2\/posts\/2778","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.insilico.jp\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.insilico.jp\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.insilico.jp\/blog\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.insilico.jp\/blog\/wp-json\/wp\/v2\/comments?post=2778"}],"version-history":[{"count":1,"href":"https:\/\/www.insilico.jp\/blog\/wp-json\/wp\/v2\/posts\/2778\/revisions"}],"predecessor-version":[{"id":2782,"href":"https:\/\/www.insilico.jp\/blog\/wp-json\/wp\/v2\/posts\/2778\/revisions\/2782"}],"wp:attachment":[{"href":"https:\/\/www.insilico.jp\/blog\/wp-json\/wp\/v2\/media?parent=2778"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.insilico.jp\/blog\/wp-json\/wp\/v2\/categories?post=2778"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.insilico.jp\/blog\/wp-json\/wp\/v2\/tags?post=2778"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}